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Lockhart, Samuel
One or more keywords matched the following properties of Lockhart, Samuel
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first name Samuel
full name Samuel N. Lockhart PhD
label Lockhart, Samuel
overview Samuel N. Lockhart, Ph.D., is a neuroscientist who has spent his research career disentangling normal brain aging from preclinical disease. He earned his Ph.D. in Neuroscience from UC Davis with Dr. Charles DeCarli, investigating the impacts of age and cerebrovascular disease on brain function and cognition, and completed a postdoctoral fellowship with Dr. William Jagust at UC Berkeley, examining how tau and amyloid accumulation affect brain structure and cognitive trajectories. He is an author of publications that have appeared in Neuron, NeuroImage, Neurology, Journal of Neuroscience, Brain, Stroke, Journal of Nuclear Medicine, and JAMA Neurology, among others. At Wake Forest, Dr. Lockhart is an Associate Professor of Internal Medicine and Gerontology and Geriatric Medicine. He plans to build a research program in multimodal neuroimaging and cognitive analyses of aging and diseases of aging, with a focus on interactions between metabolic dysfunction and vascular and degenerative pathology.
One or more keywords matched the following items that are connected to Lockhart, Samuel
Item TypeName
Concept Organ Size
Concept Longitudinal Studies
Concept Psychiatric Status Rating Scales
Concept Stilbenes
Concept Computer Simulation
Concept Cohort Studies
Concept Retrospective Studies
Concept Severity of Illness Index
Concept Photic Stimulation
Concept National Institute on Aging (U.S.)
Concept Cross-Over Studies
Concept Spin Labels
Concept Single-Blind Method
Concept Case-Control Studies
Concept Prospective Studies
Concept Cross-Sectional Studies
Concept Brain Stem
Concept Stress, Psychological
Concept Multiple Sclerosis
Concept United States
Concept Sex Characteristics
Concept Corpus Striatum
Concept Follow-Up Studies
Academic Article Tau and ß-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging.
Academic Article Amyloid and tau PET demonstrate region-specific associations in normal older people.
Academic Article Episodic memory function is associated with multiple measures of white matter integrity in cognitive aging.
Academic Article White matter hyperintensities and their penumbra lie along a continuum of injury in the aging brain.
Academic Article Tract-Specific Correlates of Neuropsychological Deficits in Patients with Subcortical Vascular Cognitive Impairment.
Academic Article White matter hyperintensities are associated with visual search behavior independent of generalized slowing in aging.
Academic Article Neuroimaging of the aging brain: introduction to the special issue of neuropsychology review.
Academic Article Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer's Disease Patients Measured Using [18F] THK-5351.
Academic Article Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease.
Academic Article Elevated 18F-AV-1451 PET tracer uptake detected in incidental imaging findings.
Academic Article White matter hyperintensities among older adults are associated with futile increase in frontal activation and functional connectivity during spatial search.
Academic Article Alzheimer Disease Signature Neurodegeneration and APOE Genotype in Mild Cognitive Impairment With Suspected Non-Alzheimer Disease Pathophysiology.
Academic Article Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease.
Academic Article The role of diffusion tensor imaging in the study of cognitive aging.
Academic Article PET Imaging of Tau Deposition in the Aging Human Brain.
Academic Article Structural imaging measures of brain aging.
Academic Article Reference Tissue-Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging.
Academic Article Prediction Model of Conversion to Dementia Risk in Subjects with Amnestic Mild Cognitive Impairment: A Longitudinal, Multi-Center Clinic-Based Study.
Academic Article Blood Pressure's Role in Alzheimer Disease Pathology.
Academic Article Diagonal Earlobe Crease is a Visible Sign for Cerebral Small Vessel Disease and Amyloid-ß.
Academic Article Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease.
Academic Article Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging.
Academic Article Centiloid method evaluation for amyloid PET of subcortical vascular dementia.
Academic Article Subthreshold Amyloid Predicts Tau Deposition in Aging.
Academic Article Machine Learning-based Individual Assessment of Cortical Atrophy Pattern in Alzheimer's Disease Spectrum: Development of the Classifier and Longitudinal Evaluation.
Academic Article Prediction Model of Conversion to Dementia Risk in Subjects with Amnestic Mild Cognitive Impairment: A Longitudinal, Multi-Center Clinic-Based Study.
Academic Article Spatially Adaptive Varying Correlation Analysis for Multimodal Neuroimaging Data.
Academic Article Prediction Models of Cognitive Trajectories in Patients with Nonamnestic Mild Cognitive Impairment.
Academic Article Sex-Related Reserve Hypothesis in Alzheimer's Disease: Changes in Cortical Thickness with a Five-Year Longitudinal Follow-Up.
Academic Article Relationships Between Tau and Glucose Metabolism Reflect Alzheimer's Disease Pathology in Cognitively Normal Older Adults.
Academic Article Amyloid involvement in subcortical regions predicts cognitive decline.
Academic Article A Nomogram for Predicting Amyloid PET Positivity in Amnestic Mild Cognitive Impairment.
Academic Article Scan-Time Corrections for 80-100-min Standardizetd Uptake Volume Ratios to Measure the 18F-AV-1451 Tracer for Tau Imaging.
Academic Article Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology.
Academic Article Distinct amyloid distribution patterns in amyloid positive subcortical vascular cognitive impairment.
Grant Biomarkers of preclinical Alzheimer disease and cognition
Academic Article The functional index for living with multiple sclerosis: development and validation of a new quality of life questionnaire.
Academic Article The contributions of MRI-based measures of gray matter, white matter hyperintensity, and white matter integrity to late-life cognition.
Academic Article Vascular dysfunction-The disregarded partner of Alzheimer's disease.
Academic Article Machine learning based hierarchical classification of frontotemporal dementia and Alzheimer's disease.
Academic Article Clinical Effects of Frontal Behavioral Impairment: Cortical Thickness and Cognitive Decline in Individuals with Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment.
Academic Article White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities.
Academic Article Sex-Related Differences in Brain Volumes and Cerebral Blood Flow Among Overweight and Obese Adults With Type 2 Diabetes: Exploratory Analyses From the Action for Health in Diabetes Brain Magnetic Resonance Imaging Study.
Academic Article Diabetes distress, illness perceptions and glycaemic control in adults with type 2 diabetes.
Academic Article Prediction of fast decline in amyloid positive mild cognitive impairment patients using multimodal biomarkers.
Academic Article Application of an amyloid and tau classification system in subcortical vascular cognitive impairment patients.
Academic Article Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer's disease: a pilot study.
Academic Article Sex-specific relationship of cardiometabolic syndrome with lower cortical thickness.
Academic Article Reduced forced vital capacity is associated with cerebral small vessel disease burden in cognitively normal individuals.
Academic Article Correction to: A new Centiloid method for 18F-florbetaben and 18F-flutemetamol PET without conversion to PiB.
Academic Article A new Centiloid method for 18F-florbetaben and 18F-flutemetamol PET without conversion to PiB.
Academic Article Differences in neuroimaging features of early- versus late-onset nonfluent/agrammatic primary progressive aphasia.
Academic Article Decreased Levels of Blood AMPKa1 but not AMPKa2 Isoform in Patients with Mild Cognitive Impairment and Alzheimer's Disease: A Pilot Study.
Academic Article Diet, psychosocial stress, and Alzheimer's disease-related neuroanatomy in female nonhuman primates.
Academic Article Head-to-Head Comparison of 18F-Florbetaben and 18F-Flutemetamol in the Cortical and Striatal Regions.
Academic Article Imaging-based indices of Neuropathology and gait speed decline in older adults: the atherosclerosis risk in communities study.
Academic Article Disease progression modelling from preclinical Alzheimer's disease (AD) to AD dementia.
Academic Article CSF glucose tracks regional tau progression based on Alzheimer's disease risk factors.
Academic Article Relationship Between Cerebrovascular Reactivity and Cognition Among People With Risk of Cognitive Decline.
Academic Article Intranasal Insulin Reduces White Matter Hyperintensity Progression in Association with Improvements in Cognition and CSF Biomarker Profiles in Mild Cognitive Impairment and Alzheimer's Disease.
Academic Article Simultaneous Covariance Inference for Multimodal Integrative Analysis.
Academic Article Associations among vascular risk factors, neuroimaging biomarkers, and cognition: Preliminary analyses from the Multi-Ethnic Study of Atherosclerosis (MESA).
Academic Article Mediterranean and Western diet effects on Alzheimer's disease biomarkers, cerebral perfusion, and cognition in mid-life: A randomized trial.
Academic Article Early Alzheimer's disease-like reductions in gray matter and cognitive function with aging in nonhuman primates.
Academic Article Intranasal insulin modulates cerebrospinal fluid markers of neuroinflammation in mild cognitive impairment and Alzheimer's disease: a randomized trial.
Academic Article Blood-based bioenergetic profiling reveals differences in mitochondrial function associated with cognitive performance and Alzheimer's disease.
Academic Article Vascular and microstructural markers of cognitive pathology.
Academic Article Optimizing quantification of MK6240 tau PET in unimpaired older adults.
Academic Article Hypertensive Aspects of Cardiometabolic Disorders Are Associated with Lower Brain Microstructure, Perfusion, and Cognition.
Academic Article Neuroimaging and clinical characteristics of cognitive migration in community-dwelling older adults.
Academic Article Corrigendum: Relationship between cerebrovascular reactivity and cognition among people with risk of cognitive decline.
Academic Article Parametric cerebral blood flow and arterial transit time mapping using a 3D convolutional neural network.
Academic Article MicroRNA expression in extracellular vesicles as a novel blood-based biomarker for Alzheimer's disease.
Academic Article Social genomics, cognition, and well-being during the COVID-19 pandemic.
Academic Article Emerging role of vascular burden in AT(N) classification in individuals with Alzheimer's and concomitant cerebrovascular burdens.
Academic Article Preliminary PET Imaging of Microtubule-Based PET Radioligand [11C]MPC-6827 in a Nonhuman Primate Model of Alzheimer's Disease.
Academic Article T cell exhaustion is associated with cognitive status and amyloid accumulation in Alzheimer's disease.
Academic Article Association of fractal dimension and other retinal vascular network parameters with cognitive performance and neuroimaging biomarkers: The Multi-Ethnic Study of Atherosclerosis (MESA).
Academic Article Mediterranean Diet Protects Against a Neuroinflammatory Cortical Transcriptome: Associations with Brain Volumetrics, Peripheral Inflammation, Social Isolation and Anxiety.
Academic Article Age and beta amyloid deposition impact gait speed, stride length, and gait smoothness while transitioning from an even to an uneven walking surface in older adults.
Academic Article Differential diagnosis of frontotemporal dementia subtypes with explainable deep learning on structural MRI.
Academic Article Mediterranean diet protects against a neuroinflammatory cortical transcriptome: Associations with brain volumetrics, peripheral inflammation, social isolation, and anxiety in nonhuman primates (Macaca fascicularis).
Academic Article Peripheral Blood Cells from Older Adults Exhibit Sex-Associated Differences in Mitochondrial Function.
Academic Article When prion disease Isn't suspected: prion disease as the cause of terminal decline in chronic mixed dementia.
Academic Article Examining a Preclinical Alzheimer's Cognitive Composite for Telehealth Administration for Reliability Between In-Person and Remote Cognitive Testing with Neuroimaging Biomarkers.
Academic Article Associations among plasma, MRI, and amyloid PET biomarkers of Alzheimer's disease and related dementias and the impact of health-related comorbidities in a community-dwelling cohort.
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  • National Institute on Aging
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